Writing on “Migraines, methylation & B vitamins”, Holford argues that supplementation with B vitamins can be useful. He offers two suitably referency links to pubmed-indexed papers. However, both links fail substantiate Holford’s claims and are the source of a little embarrassment for one who so frequently upbraids others for their knowledge or being up to date with recent research.
The first article linked looks at the connection between genetics and migraines. It does not support Holford’s position re supplementation (although it suggests that supplementation may be worth investigating). We wonder if Holford meant to link another study?
The second article linked by Holford is an open label study with no control group. We don’t have access to the journal, but if this PDF is the full article then the study in question only involved 26 patients. We would suggest that Holford conducts a more detailed review of the literature on this topic, and that Biocare consider funding some good quality research on the pills they sell: a small, open label study such as this is a poor basis for treatment recommendations.
The first link is to the wrong paper and we can’t identify the one that he intended. The second link to ‘evidence’ involves a tiny, open-label study with unimpressive results that the authors admit disappear if subjected to a more rigorous analysis.
This may explain the fact that in our study we could demonstrate a significantly reduced intake of triptans [in conjuction with riboflavin supplements]. If we have looked for all abortive agents, our results would not have reached statistical significance. [Emphasis added.]
In fact, never mind the literature review, a blog post with accurate linking and appropriate discussion of a paper’s contents would be good. Surely someone with the research resources of Patrick Holford and Biocare could manage that – surely?