Category Archives: home test

Patrick Holford Claims More People Die, Prematurely, From Cardiovascular Disease Than Actually Die, Prematurely, From All Causes

Patrick Holford on ITV Lunchtime 16 April 2008
Former Visiting Professor Patrick Holford is Head of Science and Education at Biocare. Despite the imprimatur of respectability about these confidence-inspiring titles, from time to time, there are disappointing errors in the content of Holford’s health advice and sales pitches for home tests and the evidence base for supplements. These errors are all the more dispiriting when one recalls that he was corrected about some of them more than two years ago. We don’t mean differences of opinion, we mean verifiable, checkable facts. When Holford persuades people to rely upon his opinion and lend credence to it because he undertakes to do the scientific research and interpret it for them then it seems inappropriate to claim that more people died, prematurely, from a specific cause than actually died, prematurely, from all causes. Continue reading

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Allergy UK Wants YorkTest IgG Food Intolerance Tests Available on NHS

I am constantly in awe of the resilience of people and companies: their nonsense can be exposed in the most public of fora and yet they bounce right back with their marketing message unchanged or tactfully edited but still ignoring the point that it is underpinned by nonsense. Former Visiting Professor Patrick Holford comes to mind as does Nas Amir Ahmadi of Detox in a Box. YorkTest (so beloved of Patrick Holford, Allergy UK, and a slew of self-declared experts as well as TV doctors) is another such company. YorkTest offers a food intolerance product that has been declared irrelevant by clinical allergists and immunologists and publicly deprecated but manages to garner pages of laudatory press coverage through its attractive press releases and to win customers because it ‘sounds science-y’. Recently, YorkTest piggybacks onto Allergy UK‘s Blossom Awareness Week to highlight the issue of allergies in children. Continue reading

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Holford on alcohol, home liver testing kits, and evidence

I had thought that the stream of Holford’s comedy health/marketing e-mails had dried up, so I was surprised to see him tell his mailing list yesterday that “One in two daily drinkers have liver dysfunction”. Not, in itself, an implausible claim. However, the evidence Holford bases it on is, not surprisingly, completely inadequate – this is not encouraging, given that Holford is trying to promote himself as an expert in addiction. Continue reading

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Homocysteine: Really Not a Crystal Ball

Former Visiting Professor Patrick Holford is still Head of Science and Education at Biocare so presumably they must believe that he enhances their reputation and scientific credibility with his advocacy of tests such as those for homocysteine (Hcy) levels and recommendations that people with high levels (as defined by him) should lower it by taking various supplements (see related reading). Continue reading

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Patrick Holford and The Whole Health Dowsing Kit

Holford and the Whole Health Dowsing Kit complete with pendulum and vitamin samples
Professor Patrick Holford of Teesside University and Head of Science and Education at Biocare frequently upbraids professionals and researchers for what he perceives as their lack of up-to-date research.

You may recall that we previously mentioned Holford’s advocacy of health dowsing as a way of diagnosing nutritional needs and said that we had seen a diagram of the kit that was for sale. Continue reading

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Patrick Holford Still Advocates IgG Testing for Food Allergies

Professor Patrick Holford of Teesside University and Head of Science and Education at Biocare frequently upbraids professionals and researchers for what he perceives as their lack of up-to-date research.

Holford’s 100%health newsletter for November 2007 is full of the usual inexactitudes and creative interpretations of quite straightforward research. He once again conflates allergies and intolerance and discusses IgG as if it is relevant to any such discussion. Continue reading

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Filed under allergies, allergy, ASA, food intolerance, food sensitivity, Holford, home test, hometesting, IgG tests, lactose intolerance, patrick holford, Scadding, supplements, yorktest

Patrick Holford, Alzheimer’s Disease, Homocysteine Tests and Supplements

Professors Patrick Holford and David Smith chose the Daily Record to announce their remarkable findings that Alzheimer’s Disease is preventable with just a “few simple diet and lifestyle changes”.

I may be new to Holford Watch but I am familiar with the Holford Test-Em Dose-Em style of Jeopardy. If the answer is, “Dose them with B vitamins” the question must have been, “What do you do after testing someone’s homocysteine levels?”.  And, what do you know, I think it has slipped its way into this article, masquerading as a “simple blood test”. Continue reading

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Filed under Alzheimer's, B12, Brain Bio Centre, Holford, home test, homocysteine, patrick holford, supplements, vitamin B12, vitamins

Patrick Holford Endorses Allergy/Intolerance Blood Test: House of Lords Wants Responsible Professionals to Cease Endorsement of Such Techniques

Patrick Holford Endorses an Allergy/Intolerance Blood Test

Professor Patrick Holford of Teesside University and Head of Science and Education at Biocare has an unerring sense for his endorsements (see, e.g., the qLink with the unconnected coil and the dLan that may enhance your exposure to EMR).

It shows commendable loyalty to one’s partners that his name is showing up in Google Sponsored Links, advertising blood tests that came in for especial criticism in this week’s report from the House of Lords on allergy and allergic disease in the UK. Continue reading

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Patrick Holford, IgG Food Intolerance Self-Testing and the House of Lords

Professor Patrick Holford of Teesside University and Head of Science and Education at Biocare is a staunch advocate of direct to consumer IgG food intolerance tests and is impressed by the “sound science” that underlies these tests. Holford is convinced that:

The evidence for IgG antibody reactions as a basis for food intolerances continues to grow, including well designed randomised controlled trials, however, some health professionals just haven’t kept up to date. Perhaps it’s because a ‘home test’ takes the power away from the professional and puts it in your hands.

However, Holford is also swayed by the scientific research for a neck pendant that protects wearers from the evil eye of electromagnetic radiation so one might be tempted to generalise from that as to the scientific credibility of some of his endorsements. Continue reading

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How Relevant Are Holford’s Claims About Homocysteine Levels? Part 2

Patrick Holford gives a remarkable overview of history to support his claims for the value of homocysteine testing in helping you “to eliminate your risk of ever having a heart attack”. He swoops from autopsies on egyptian mummies to unsubstantiated opinions on the prevalence of heart disease in late 19th century America via some mangled statistics on the risk of premature death from cardiovascular disease in the UK, before alighting on a study of restenosis to justify his claims.

One of the most common surgical procedures for those with coronary artery disease is angioplasty. It involves inserting catheter tubing containing a small balloon into arteries around the heart. The balloon is inflated to flatten deposits of atherosclerotic plaques blocking the artery, so blood can once again flow to the heart.

Like bypass surgery, angioplasty is often not a permanent cure, and after surgery the arteries may reclog in the treated area – a very undesirable condition called restenosis…

Restenosis of the coronaries is much more likely if your H score is high, according to research at the Swiss Cardiovascular Centre in Bern. (4) In a nutshell, this means the higher your H score, the faster your coronary arteries will narrow again after surgery, so there’s little point having an angioplasty without testing for and treating high homocysteine.

Unfortunately, this is only part of the story; the role of homocysteine levels in predicting restenosis is not that straightforward. Holford has frequently expressed his concern about the mis-citing of research literature and possible suppression of inconvenient findings, so it seems appropriate to look at the research literature for homocysteine and restenosis in a little more detail to see if he is representing the literature in an evenhanded way.

Back in 2000, Dr. Steven Miner and his colleagues published an interesting study into possible correlations between homocysteine concentrations and restenosis following angioplasty. This was a well-designed, prospective study. The authors were confident in their conclusion that raised homocysteine levels do not predict the likelihood of restenosis.

The range of plasma homocysteine concentrations in this study is consistent with that seen in other studies,[refs] as is the trend toward an increased mean homocysteine concentration in homozygotes for the MTHFR 677T genotype.[ref] However, ours is the first published study to investigate the possible correlation between homocysteine concentrations and restenosis after PTCA and clearly shows the absence of any positive correlation. This lack of effect is apparent in patients undergoing PTCA alone and in with those receiving adjuvant stenting. No threshold effect is apparent. The adequate sample size, near complete follow-up, and the trend toward a negative correlation makes the possibility of a false-negative study extremely unlikely. [Emphasis added.]

There are several other studies that do not find a signficant relationship for homocysteine and restenosis:

2002 Relation of homocysteine, vitamin B(12), and folate to coronary in-stent restenosis “These results suggest that homocysteine, folate, and vitamin B(12) are not related to the angiographically determined rate of coronary in-stent restenosis after 6 months.”

2005 Clinician Update Homocysteine and Its Effects on In-Stent Restenosis cites a number of earlier clinical trials that fail to show a relationship between high homocysteine levels and restenosis. They note that several trials are in progress and conclude: “Until complete results of these studies become available, screening for hyperhomocystinemia in patients undergoing coronary stenting is only recommended in the case of premature atherosclerotic disease (patients homocysteine-lowering therapy might have a deleterious effect in patients treated with stent implantation“. [Emphasis added.]

2006 A prospective patient observational study of the role of hyperhomocysteinemia in restenosis in patients undergoing infrainguinal angioplasty or bypass procedures. “This study does not support the hypothesis that HHCy is associated with an increased risk of restenosis after vascular intervention.”

2006 Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. This is one of the studies that Holford acknowledges and disputes; however, the authors conclude: “Folic acid supplementation has not been shown to reduce risk of cardiovascular diseases or all-cause mortality among participants with prior history of vascular disease. Several ongoing trials with large sample sizes might provide a definitive answer to this important clinical and public health question”.

2006 Efficacy of folic acid therapy for prevention of in-stent restenosis: a randomized clinical trial. “Treatment with folic acid does not decrease the rate of restenosis and need for revascularization of the target lesion after stent-percutaneous coronary angioplasty.”

2006 Post-interventional homocysteine levels: failure as a predictive biomarker of in-stent restenosis. “[W]e hypothesise that homocysteine may not serve as a safe and independent biomarker of in-stent restenosis after a six months period following percutaneous coronary stenting.”

Holford uses a restenosis study that is not validated by other researchers to assemble a supporting platform of evidence to demonstrate the value of widespread testing of homocysteine levels.

Holford and Braly claim that homocysteine levels are a “chemical crystal ball”. It would be profoundly useful and cost-effective if homocysteine levels were capable of predicting the need for restenosis or could function as a simple index of your current and future health. Unfortunately, it doesn’t seem as if a homocysteine test can bear the mantle of so much responsibility: there isn’t even a consensus of opinion as to whether or not it has a predictive role for restenosis although the evidence is increasingly against it.

Regular homocysteine tests (as recommended 2-3 times a year to establish your baseline levels and tweak/maintain them with vitamin supplements) cost money; from around £70-75 per test. The recommended H Factors vitamin supplement will cost from £41.60 for 90 days to £41.60 for 30 days, depending on the recommended dose. There is no information about the bioavailability of the contents, so I don’t know if it is appropriate to expect your GP or Practice Nurse to advise you on your H Factors dosage; you might need to pay to consult a nutritionist or similar. A nutritionist might base his/her recommendations on an inappropriate interpretation of research and some unsupported beliefs.

You may well be comforted at the thought that your homocysteine levels are low or within bounds; however, it might be helpful if you are confident that there is good quality research to support the value of this. In subsequent parts of the review of Holford’s claims for homocysteine, we will look at trials that report that homocysteine levels can be reduced by vitamin supplementation but that this has no affect on clinical outcomes; e.g., you might spend between £700-1000 per year and successfully lower your homocysteine levels but still have raised blood pressure.

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Filed under folate, folic acid, H Factors, home test, homocysteine, james braly, patrick holford, Refsum, restenosis, vitamin B12, vitamins