Tag Archives: CVD

Patrick Holford blogs cohort study which finds that “Multivitamin use was not related to total mortality”

I was interested to see Holford blogging about Pocobelli et al’s recent article on “Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality”. Holford reports the study as finding that “Multivitamin use cuts heart disease risk”. However, I have a number of concerns about Holford’s interpretation of this study Continue reading

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Patrick Holford Claims More People Die, Prematurely, From Cardiovascular Disease Than Actually Die, Prematurely, From All Causes

Patrick Holford on ITV Lunchtime 16 April 2008
Former Visiting Professor Patrick Holford is Head of Science and Education at Biocare. Despite the imprimatur of respectability about these confidence-inspiring titles, from time to time, there are disappointing errors in the content of Holford’s health advice and sales pitches for home tests and the evidence base for supplements. These errors are all the more dispiriting when one recalls that he was corrected about some of them more than two years ago. We don’t mean differences of opinion, we mean verifiable, checkable facts. When Holford persuades people to rely upon his opinion and lend credence to it because he undertakes to do the scientific research and interpret it for them then it seems inappropriate to claim that more people died, prematurely, from a specific cause than actually died, prematurely, from all causes. Continue reading

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Alternative Nutrition bingo: we predict industry responses to the JAMA trial of vitamin C and E

The Journal of the American Medical Association has recently published a good quality, placebo-controlled, randomised, double-blind trial looking at whether vitamin C and E supplementation can reduce cardiovascular events. It ran for 10 years, and included “14 641 US male physicians enrolled, who were initially aged 50 years or older, including 754 men (5.1%) with prevalent cardiovascular disease at randomization.” The trial concluded that “[t]hese data provide no support for the use of these supplements for the prevention of cardiovascular disease in middle-aged and older men.”

I was surprised to see that the alternative nutrition industry has not yet responded to this – I was waiting with bated breath for Sir Cliff Richard’s definitive critique of the science – so I thought that I would respond on their behalf: frankly, the alternative nutrition industry’s response to such trials has become tediously predictable so there seems to be little point in waiting.

I will list a number of likely industry responses below; I will then enjoy the small satisfaction of ticking them off when they appear in industry press releases: Continue reading

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Homocysteine: Really Not a Crystal Ball

Former Visiting Professor Patrick Holford is still Head of Science and Education at Biocare so presumably they must believe that he enhances their reputation and scientific credibility with his advocacy of tests such as those for homocysteine (Hcy) levels and recommendations that people with high levels (as defined by him) should lower it by taking various supplements (see related reading). Continue reading

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Polypills or Vitamins for Homocysteine and Cardiovascular Risks: the Hype is Ahead of the Evidence

You may have experienced déjà vu over the last few days if you’ve been reading excited accounts about polypills for the over-55s (there was a lot of Oh Brave New World about the potential for polypills in 2003). The claims are that polypills will prevent 100,000 premature deaths a year and also prevent up to 80% of heart attacks and strokes. The polypills will contain a cholesterol-reducing statin; three types of medicine to lower blood pressure (thiazide, aspirin and beta-blockers); and folic acid to reduce levels of homocysteine (Hcy). Continue reading

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